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Publications 2005 (IKP + RBK)

  • Abraham BK, Justenhoven C, Pesch B, Harth V, Weirich G, Baisch C, Rabstein S, Ko YD, Brüning T, Fischer HP, Haas S, Brod S, Oberkanins C, Hamann U, and Brauch H: Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer. Cancer Epidemiol Biomarkers Prevention 2005;14:1102-7
  • Abraham BK, Fritz P, McClellan M, Hauptvogel P, Athelogou M, and Brauch H: Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res 2005;11:1154-9
  • Abuharbeid S, Apel J, Zugmaier G, Knabbe C, Sander M, Gilbert S, Czubayko F, Aigner A: Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells. Naunyn-Schmiedebergs Arch Pharmacol 2005;371(2):141-51
  • Alscher DM, Braun N, Biegger D, Stuelten C, Gawronski K, Mürdter TE, Kuhlmann U, Fritz P: Induction of metallothionein in proximal tubular cells by Zinc and its potential as an endogenous antioxidant. Kidney Blood Pressure Res 2005;28: 127-33
  • Atkins DJ, Gingert C, Justenhoven C, Schmahl GE, Bonato MS, Brauch H and Störkel S: Concommittant deregulation of HIF1α and cell cycle proteins in VHL mutated renal cell carcinomas. Virchows Archiv 2005;447:634-42
  • Bachmakov I, Rekersbrink S, Hofmann U, Eichelbaum M, Fromm MF: Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein. Naunyn-Schmiedeberg's Arch Pharmacol 2005;371: 195-201
  • Bergheim I, Harsch S, Mueller O, Schimmel S, Fritz P, Stange EF: Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. J Lipid Res 2005;47(1): 42-50
  • Bredthauer D, Becker C, Eichner B, Koczy P, Nikolaus T: Factors relating to the use of physical restraints in psychogeriatric care: a paradigm for elder abuse. Z Gerontol Geriatr 2005:38: 10-8
  • Burk O, Arnold KA, Geick A, Tegude H, Eichelbaum M: A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression. Biol Chem 2005;386: 503-13
  • Burk O, Arnold KA, Nussler AK, Schaeffeler E, Efimova E, Avery BA, Avery MA, Fromm MF, Eichelbaum M: Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol 2005;67(6):1954-65
  • Cummings RFC, Herrlinger KR, Gorard DA, McIntyre AS, Travis SPL and Jewell DP: Oral methotrexate in ulcerative colitis. Aliment Pharmacol Therap 2005;21:385-9
  • Dietrich M, Grundmann L, Kurr K, Valinotto L, Saussele T, Schmid RD, Lange S: Recombinant production of human microsomal cytochrome P450 2D6 in the methylotrophic yeast Pichia pastoris. Chem Bio Chem 2005;11: 2014-22
  • Elter T, Borchmann P, Schulz H, Reiser M, Trelle S, Schnell R, Jensen M, Staib P, Schinkothe T, Stutzer H, Rech J, Gramatzki M, Aulitzky W, Hasan I, Josting A, Hallek M, Engert A. Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-Cell chronic lymphocytic leukemia: Results of a Phase II Trial. Clin Oncol 2005;23(28):7024-31
  • Evangelista A, Mukherjee D, Mehta RH, O`Gara PT, Fattori R, Cooper JV, Smith DE, Oh JK, Hutchison S, Sechtem U, Isselbacher EM, Nienaber CA, Pape LA, Eagle KA for the International Registry of Aortic Dissection (IRAD) Investigators: Acute intramural hematoma of the aorta: A mystery in evolution. Circulation 2005;111:1063-70
  • Fritz P, Cabrera CM, Dippon J, Gerteis A, Simon W, Aulitzky WE, van der Kuip H: c-erbB2 and topoisomerase II alpha protein expression independently predict poor survival in primary human breast cancer: a retrospective study. Breast Cancer Res 2005;7(3):R374-84
  • Fux R, Mörike K, Prohmer AM, Delabar U, Schwab M, Schaeffeler E, Lorenz G, Gleiter CH, Eichelbaum M, Kivistö KT: Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study. Clin Pharmacol Ther 2005;78:378-87
  • Fux R, Schwab M, Thon KP, Gleiter CH, Fritz P: Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. Clin Cancer Res 2005;11:4754-60
  • Gläser H, Drescher S, Eichelbaum M, Fromm MF: Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes. Br J Clin Pharmacol 2005;59:199-206
  • Haberl M, Anwald B, Klein K, Weil R, Fu C, Gepdiremen A, Zanger UM, Meyer UA, Wojnowski L: Three haplotypes associated with CYP2A6 phenotypes in Caucasians. Pharmacogenet Genomics 2005;15:609-24
  • Hartmann U, Balabanov S, Ziegler P, Fellenberg J, van der Kuip H, Duyster J, Lipp HP, Bokemeyer C, Kanz L, Brümmendorf TH: Telomere length and telomerase activity in the BCR-ABL-transformed murine Pro-B cell line BaF3 is unaffected by treatment with imatinib. Experim Hematol 2005;33(5):542-9
  • Hauser IA, Schaeffeler E, Gauer S, Scheuermann EH, Wegner B, Gossmann J, Ackermann H, Seidl C, Hocher B, Zanger UM, Geiger H, Eichelbaum M, Schwab M: ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation. J Am Soc Nephro 2005;16(5):1501-1511
  • Heinkele G., Mürdter T.E. Synthesis of [H]-labelled phase-I-metabolites using 1-[H]-pyridinium hydrochloride. Labelled Comp Radiopharm 2005;48:457-61
  • Herrlinger KR, Cummings JR, Barnardo CNM, Schwab M, Ahmad T and Jewell DP: The pharmacogenetics of methotrexate in inflammatory bowel disease. Pharmacogenet Genomics 2005;15(10):705-11
  • Homann N, Klarmann U, Fellermann K, Bruning A, Klingenberg-Noftz R, Witthoft T, Stange EF, Ludwig D: Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn's disease. Inflamm Bowel Dis 2005;11(2):126-32
  • Jaremko M, Justenhoven C, Abraham BK, Schroth W, Fritz P, Brod S, Vollmert C, Illig T, and Brauch H: MALDI-TOF MS and TaqMan assisted SNP genotyping of DNA isolated from formalin-fixed and paraffin embedded tissues (FFPET) Human Mutation 2005;25:232-8
  • Justenhoven C, Hamann U, Pierl CB, Rabstein S, Pesch B, Harth V, Baisch C, Vollmert C, Illig T, Brüning T, Ko Y, Brauch H for the GENICA Network: One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA Study from Germany. Cancer Epidemiol Biomarkers Prevention 2005;14:3015-8
  • Kamdem LK, Streit F, Zanger UM, Brockmöller J, Oellerich M, Armstrong VW, Wojnowski L: Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus. Clin Chem 2005;51:1374-81
  • Kivistö KT, Grisk O, Hofmann U, Meissner K, Moritz KU, Ritter C, Arnold K, Lütjohann D, von Bergmann K, Kloting I, Eichlbaum M, Kroemer HK: Disposition of oral and intravenous pravastatin in MRP2-deficient TR-rats. Drug Metab Dispos 2005;33:1593-6
  • Kivistö KT, Niemi M, Schaeffeler E, Pitkälä K, Tilvis R, Fromm MF, Schwab M, Lang F, Eichelbaum M, Strandberg T: CYP3A5 genotype is associated with diagnosis of hypertension in elderly patients: data from the DEBATE study. Am J Pharmacogenomics 2005;5:191-5
  • Kleideiter E, Bangerter U, Schwab M, Boukamp P, Koscielniak E, Klotz U, Greil J. Telomeres and telomerase in paediatric patients with T-cell acute lymphoblastic leukaemia (T-ALL). Leukemia 2005;19:296-8
  • Klein K, Lang T, Saussele T, Barbosa-Sicard E, Schunck WH, Eichelbaum M, Schwab M, Zanger UM: Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz. Pharmacogenet. Genomics 2005;15:861-73
  • Koczy P, Klie T, Kron M, Bredthauer D, Rissmann U, Branitzki S, Guerra V, Klein A, Pfundstein T, Nikolaus T, Sander S, Becker C: Effektivität einer multifaktoriellen Intervention zur Reduktion von körpernaher Fixierung bei demenzerkrankten Heimbewohnern. Z Gerontol Geriatr 2005;38: 33-39
  • Lamp SE, Jorstad EC, Hauer K, Becker C on behalf of PROFANE (Prevention of Falls Network Europe): Development of a common outcome data set for fall injury prevention trials: the Prevention of Falls Network Europe consensus. J Am Geriatr Soc 2005;53(9):1618-22
  • Lenz G, Dreyling M, Hoster E, Wormann B, Duhrsen U, Metzner B, Eimermacher H, Neubauer A, Wandt H, Steinhauer H, Martin S, Heidemann E, Aldaoud A, Parwaresch R, Hasford J, Unterhalt M, Hiddemann W: Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol 2005;23(9):1984-92
  • Lenzen MJ, Boersma E, Bertrand ME, Maier W, Moris C, Piscione F, Sechtem U, Stahle E, Widimsky P, de Jaegere P, Scholte op Reimer WJM, Mercado N, Wijns W: Management and outcome of patients with established coronary artery disease: the Euro Heart Survey on coronary revascularization. Eur Heart J 2005;26:1169-79
  • Lichtenberg A, Dumlu G, Walles T, Maringka M, Ringes-Lichtenberg S, Ruhparwar A, Mertsching H, Haverich A: A multifunctional bioreactor for three-dimensional cell (co)-culture. Biomaterials 2005;26:555-62
  • Lindemann U, Hock A, Stuber M, Keck W, Becker C: Evaluation of a fall detector based on accelerometers: a pilot study. Med Biol Eng Comput 2005;43:548-51
  • Mahrholdt H, Zhydkov A, Hager S, Mangin M, Meinhardt G, Vogelsberg H, Wagner A, Sechtem U: Left ventricular wall motion abnormalities and wall thinning can cause false positive results of routine SPECT perfusion imaging for detection of myocardial infarction. Eur Heart J 2005;26:2127-35
  • Mehta RH, Manfredini R, Bossone E, Fattori R, Evagelista A, Boari B, Cooper JV, Sechtem U, Isselbacher EM, Nienaber CA, Eagle KA, International Registry of Acute Aortic Dissection (IRAD) Investigators: The winter peak in the occurrence of acute aortic dissection is independent of climate. Chronobiol Int 2005;22:723-729
  • Mertsching H, Walles T, Hofmann M, Schanz J, Knapp WH: Engineering of a vascularised scaffold for artificial tissue and organ generation. Biomaterials 2005;26:6610-7
  • Moehring A, Wohlbold L, Aulitzky WE, van der Kuip H: Role of poly(ADP-ribose) polymerase activity in imatinib mesylate-induced cell death. Cell Death Differentiation 2005;12(6):627-36
  • Mukherjee D, Evangelista A, Nienaber CA, Sechtem U, Suzuki T, Trimarchi S, Llovet A, Myrmel T, O’Gara PT, Fang J, Cooper JV, Oh JK, Januzzi JL, Hutchison S, Fattori R, Pape LA, Isselbacher EM, Eagle KA: Implications of periaortic hematoma in patients with acute aortic dissection (from the International Registry of Acute Aortic Dissection) Am J Cardiol 2005;96:1734-8
  • Neurath MF, Kiesslich R, Teichgräber U, Fischer C, Hofmann U, Eichelbaum M, Galle PR, Schwab M: 6-Thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn’s disease. Clin Gastro Hepatol 2005;3: 1007-14
  • Niemi M, Backman JT, Kajosaari LI, Leathart JB, MPhil, Neuvonen M, Daly AK, Eichelbaum M, Kivistö KT, Neuvonen PJ: Polymorphic organic anion transporting polypeptide 1B1 (OATP1B1) is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther 2005;77: 468-78
  • Niemi M, Kivistö KT, Hofmann U, Schwab M, Eichelbaum M, Fromm MF: Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1). Br J Clin Pharmacol 2005;59: 602-4
  • Niemi M, Neuvonen PJ, Hofmann U, Backman JT, Schwab M, Lütjohann D, von Bergmann K, Eichelbaum M, Kivistö KT: Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17. Pharmacogenet Genomics 2005;15: 303-9
  • Oechtering D., Schiltmeyer B., Hempel G., Schwab M., Wurthwein G., Mürdter T., Klingebiel T., Vormoor J., Gruhn B., Fleischack G., Boos J: Toxicity and pharmacokinetics of i.v. busulfan in children before stem cell transplantation. Anticancer Drugs 2005;16: 337-44
  • Pesch B, Ko Y, Brauch H, Hamann U, Harth V, Rabstein S, Pierl C, Fischer HP, Baisch C, Justenhoven C, Ranft U, Brüning T for the GENICA Network: Factors modifying the association between hormone-replacement therapy and breast cancer risk. Eur J Epidemiol 2005;20:699-711
  • Piotrowska K, Kleideiter E, Mürdter TE, Taetz S, Baldes C, Schaefer U, Lehr C-M, Klotz U: Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors. Lab Invest 2005;85:1565-9
  • Rapp K, Schroeder J, Klenk J, Stoehr S, Ulmer H, Concin H, Diem G, Oberaigner W, Weiland SK: Obesity and incidence of cancer: a large cohort study of over 145000 adults in Austria. Br J Cancer 2005;93:1062-7
  • Rapp K, Schick KH, Bode H, Weiland SK: Type of kindergarten and other potential determinants of overweight in pre-school children. Public Health Nutr 2005;8 (6): 642-9
  • Rashid MU, Jakubowska A, Justenhoven C, Harth V, Pesch B, Baisch C, Pierl CB, Brüning T, Ko Y, Benner A, Wichmann HE, Brauch H, Hamann U on behalf of the GENICA Network: German populations with infrequent CHEK2*1100delC and minor associations with early-onset and familial breast cancer. Eur J Cancer 2005;41(18): 2896-903
  • Richter T, Schwab M, Eichelbaum M, Zanger UM: Inhibition of human CYP2B6 by thioTEPA is irreversible and mechanism-based. Biochem Pharmacol 2005;69:517-24
  • Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H; Vorarlberg Health Monitoring and Promotion Program Study Group: Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults. Circulation 2005;112 (14): 2130-7
  • Schroeder TH, Hansen M: Effects of fresh versus old stored blood in the priming solution on whole blood lactate levels during paediatric cardiag surgery. Perfusion 2005;20: 17-19
  • Schultheiss D, Gabouev Al, Cebotari S, Tudorache I, Walles T, Schlote N, Wefer J, Kaufmann PM, Haverich A, Jonas U, Stief CG, Mertsching H: Biological vascularised matrix for bladder tissue engineering: Matrix preparation, reseeding technique and short-term implantation in a procine model. J Urology 2005;173:276-280
  • Schwab M, Klotz U, Hofmann U, Schaeffeler E, Leodolter A, Malfertheiner P, Treiber G: Esomeprazole induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19 – evidence from clinical and pharmacokinetic data. Clin Pharmacol Ther 2005;78: 627-34
  • Schwarz UI, Seemann D, Oertel R, Miehlke S, Kuhlisch E, Fromm MF, Kim RB, Bailey DG, Kirch W: Grapefruit juice ingestion significantly reduces talinolol bioavailability. Clin Pharmacol Ther 2005;77:291-301
  • Schuler MS, Durdak C, Hösl NM, Klink A, Hauer K, Oster P, Du X: Accupuncture treatment of geriatric patients with ischemic stroke: a randomized, double-controlled, single-blind study. J Am Geriatr Soc 2005;53:549
  • Stanulla M, Schaeffeler E, Flohr T, Cario G, Schrauder A, Zimmermann M, Welte K, Ludwig WD, Bartram CR, Zanger UM, Eichelbaum M, Schrappe M, Schwab M: Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. JAMA 2005;293(12):1485-9
  • Stanulla M, Schäffeler E, Arens S, Rathmann A, Schrauder A, Welte K, Eichelbaum M, Zanger UM, Schrappe M, and Schwab M: GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukaemia. Int J Hematol 2005;81:39-44
  • Teml A, Schwab M, Harrer M, Miehsler W, Schaeffeler E, Dejaco C, Mantl M, Schneider B, Vogelsang H, Reinisch W: A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis. Scand J Gastroenterol 2005;40(10):1205-13
  • Van der Bos EJ, Thompson RB, Wagner A, Mahrholdt H, Morimoto Y, Thomson LE, Wang LH, Duncker DJ, Judd RM, Taylor DA: Functional assessment of myoblast transplantation for cardiac repair with magnetic resonance imaging. Eur J Heart Failure 2005;7: 435-43
  • von Bubnoff N, Veach DR, van der Kuip H, Aulitzky WE, Sanger J, Seipel P, Bornmann WG, Peschel C, Clarkson B, Duyster J. A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor. Blood 2005;105(4):1652-9
  • Witthoft T, Pilz CS, Fellermann K, Nitschke M, Stange EF, Ludwig D: Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2). Dig Dis Sci 2005;50(7):1252-9
  • Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schäffeler E, Schwab M, Linzmaier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL: Reduced paneth cell α-defensins in ileal Crohn`s disease. PNAS 2005;102:18129-34
  • Yardley L, Todd C, Beyer N, Hauer K, Kempen G, Piot-Ziegler C: Development and initial validation of the Falls Efficacy Scale International (FES-I). Age Ageing 2005;34: 614-9
  • Xin H, Fischer C, Schwab M, Klotz U: Thiopurine S-methyltransferase as a target for drug interactions. Eur J Clin Pharmacol 2005;61: 395-8
  • Xin H, Fischer C, Schwab M, Klotz U: Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2005;21:1105-9
  • Zanger UM, Klein K, Richter T, Toscano C, Zukunft J: Impact of genetic polymorphism in relation to other factors on expressin and function of human drug-metabolizing P450s. Toxicol Mechan Methods 2005;15:121-4
  • Zukunft J, Lang T, Richter T, Hirsch-Ernst KI, Nussler AK, Klein K, Schwab M, Eichelbaum M, Zanger UM: A natural CYP2B6 TATA box-polymorphism (-82T>C) leading to enhanced transcription and relocation of the transcriptional start site. Mol Pharmacol 2005;67(5):1772-82
  • Albers C, Bojack B, Heckmann J, Kirschner-Herrmanns R, Kümmerle S, Müller H, Mühlich S, Nemitz G, Pfisterer M, Schlusche-Flömer B, Wiedmann A: Leitlinien Harninkontinenz der Deutschen Gesellschaft für Geriatrie. Europ J Geriatr 2005;7:1-44
  • Aulitzky W.E. in Lehnert/Werdan. „Innere Medizin essential“ 4. Auflage 2005. Georg Thieme Verlag
  • Aulitzky W.E., Peschel C., Fischer T., Huber C. Chronische myeloische Leukämie (CML). In „Kompendium Internistische Onkologie“, 4. Auflage 2005 Herausgeber: Schmoll, Höffken, Possinger. Springer-Verlag
  • Becker C, Koczy P, Rissmann U, Lindemann B: Medizin und Altenheim. Z Gerontol Geriatr 2005;38:24-7
  • Benzinger P, Alscher DM: Unbehandelte Homocystinurie im Erwachsenenalter. Dtsch Med Wochenschr 2005;130:2439-43
  • Brauch, H: Die VHL-Erkrankung: die heutige Vorstellung wie ein Genotyp zum Phänotyp führt. VHL Rundbrief, Heft 2005;2:4-9
  • Eichelbaum M, Schwab M: Pharmakogenetik. Monatsschrift Kinderheilk 2005;153:741-50
  • Gebhard F, Einsiedel T, Stengel D, Liener U, Kinzl L, Becker C: Alterstraumatologie in Deutschland – derzeitiger Stand und zukünftige Entwicklung. OP-Journal 2005;21:106-9
  • Herrlinger K, Stange EF, Schröder O, Stein J, Buhr HJ, Kroesen AJ, in Caspary, Mössner, Stein (Herausgeber): Chronisch entzündliche Darmerkrankungen. Therapie gastroenterologischer Krankheiten. Springer-Verlag, 2005;249-87
  • Herrlinger K, Stange EF. Immunsuppressive und biologische Therapieoptionen bei chronisch entzündlichen Darmerkrankungen. Gastroenterologie up2date 2 2005;145-63
  • Icks A, Becker C, Kunstmann W: Sturzprävention bei Senioren: Eine interdisziplinäre Aufgabe. Deutsches Ärzteblatt 2005;31-32:A2150-2
  • Jorstad EC, Hauer K, Becker C, Lamb SE; ProFaNE Group. Measuring the psychological outcomes of falling: a systematic review. J Am Geriatr Soc 2005;53:501-10
  • Jorstad EC, Hauer K, Becker C, Bonnefoy M, Nakash RA, Skelton DA, Lamb SE. Suitability of physical activity questionnaires for older adults in fall-prevention trials: a systematic review. J Aging Phys Act 2005;13:461-81
  • Klotz U, Schwab M: Budesonid und chronisch entzündliche Darmerkrankungen. Verdauungskrankheiten 2005;23:148-56
  • Klotz U, Schwab M: Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease. Adv Drug Delivery Rev 2005;57:267-79
  • Klotz U: Colonic targeting of aminosalicylates for the treatment of ulcerative colitis. Dig Liver Dis 2005;37:381-8
  • Klotz U: Aus der Sicht eines klinischen Pharmakologen – Pharmakologie der Protonenpumpenhemmer. Pharmazie in unserer Zeit 2005;34: 200-4
  • Klotz U: Reassessment of the benefit/risk-ratio of selective COX-2-inhibitors. Swiss Medical Weekly 2005;135:166-8
  • Klotz U: The clinical impact of mesalazine for research and therapy in inflammatory bowel disease. In: Gastroenterology Yesterday-Today-Tomorrow: A Review and Preview; G. Adler, A.L. Blu, H.-E. Blum, U. Leuschner; M.P. Manns, J. Mössner, R.B. Sartor, J. Schölmerich (Eds), Springer, Dordrecht/The Netherlands, 2005;305-13
  • Klotz U:Therapeutische Optionen zur Vermeidung von NSAR-bedingten gastrointestinalen Läsionen. Verdauungskrankheiten 2005;23:85-94
  • Krueger WA, Schroeder TH, Hansen M: Pharmacokinetics of antibiotics during continuous renal replacement therapy. In: Yearbook of intensive care and emergency medicine; J.-L. Vincent (Eds), Springer 2005;349-59
  • Lindemann U, Schiele A, v. Tiedemann A: Aufgaben der Ergotherapie in der Sturzprävention bei älteren Menschen. Ergotheraphie & Rehabilitation 2005;6:6-10
  • Mahrholdt H, Wagner A, Judd RM, Sechtem U, Kim RJ: Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J 2005;26:1461-74
  • Oster P, Pfisterer M, Schuler M, Hauer K: Körperliches Training im Alter. Z Gerontol Geriat 200;38Suppl.1:I/10-I/13
  • Schmid M, Fellermann K, Wehkamp J, Stange EF: Barrieredefekt bei chronisch entzündlichen Darmerkrankungen. Folgerungen für die Praxis. Verdauungskrankheiten 2005;23:175-180
  • Schwab M, Schäffeler E, Klotz U, Stange E: Klinisch-pharmakologische Aspekte bei der Azathioprintherapie. Verdauungskrankheiten 2005;23:66-79
  • Stange EF, Schmid M, Fellermann K, Wehkamp J: Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance. Schweiz Rundsch Med Prax 2005;94(37):1429-1432
  • Treiber G, Kist M, Klotz U, Peitz U, Malfertheiner P: Therapie der Helicobacter pylori- Infektion - klinische, mikrobiologische und pharmakologische Aspekte. Dtsch Ärzteblatt 2005;102:A1883-1888
  • van der Kuip H, Wohlbold L, Oetzel C, Schwab M, Aulitzky WE. Mechanisms of clinical resistance to small molecule tyrosine kinase inhibitors targeting oncogenic tyrosine kinases. Am J Pharmacogenomics 2005;5:101-12
  • Wagner H, Mahrholdt H, Kim RJ, Judd RM: Use of cardiac magnetic resonance to assess viability. Curr Cardiol Rep 2005;7:59-64
  • Wehkamp J, Fellermann K, Herrlinger KR, Bevins CL, Stange EF. Defensins in gastrointestinal diseases. Nature Clin. Pract.GastroHep 2005;2(09):406-15
  • Wehkamp J, Fellermann K, Stange EF. Human defensins in Crohn's disease. Chem Immunol Allergy 2005;86:42-54
  • Wehkamp J, Stange EF. NOD2 mutation and mice: no Crohn's disease but many lessons to learn. Trends Mol Med 2005;11(7):307-9
  • Wehkamp J, Schmid M, Fellermann K, Stange EF. Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn’s disease. J Leukoc Biol 2005;77:460-5
  • Weiss H: Wenn das Geschehene erst dann geschieht, wenn wir es denken können – Überlegungen zur Konstruktion des inneren Raums und zur zeitlichen Rekonstruktion. Psyche – Z Psychoanal 2005;59(Beiheft 2005):65-77
  • Weiss H: Borderline-Organisationen und Missrepräsentationen der Raum-Zeit-Erfahrung in Zuständen seelischen Rückzugs. In: Zeit und Raum im psychoanalytischen Denken. Frühjahrstagung 2005, Deutsche Psychoanalytische Vereinigung (DPV) 2005;51-72
  • Alscher DM, Mettang T: Procalcitonin in peritoneal dialysis – a useful marker of inflammation? PDI 2005;25:441
  • Alscher DM: Principles of peritoneal dialysis. EDTNA/ERCA Journal XXXI 2005;3:124
  • Schieber M, Sechtem U: Fragen aus der Praxis: Kombination von Antiagulans mit Thrombozytenaggregationshemmer? Dtsch med Wochenschr 2005;130:2725
  • Sechtem U, Voehringer M: The clinical role of ’non-invasive’ coronary angiography by multidetector spiral computed tomography: yet to be defined. Eur Heart J 2005;26: 1942-4
  • Stange EF. The case against using 5-aminosalicylates in Crohn’s disease: con. Inflamm Bowel Dis 2005;11(6):613-5
Habilitations
  • Becker, Claus
    Prädiktion und Prävention von Stürzen und sturzbedingten Verletzungen von Bewohnern in Langzeitpflegeeinrichtungen. Medizinische Fakultät der Universität Ulm, 2005

PhD/MD Theses
  • Hauer, Klaus
    Gebrechlichkeit und Stürze im Alter – Ursachen und Interventionsstrategien. Medizinische Fakultät der Ruprecht-Karls-Universität Heidelberg 2005
  • Igel, Svitlana
    Untersuchungen zur Assoziation von ß1-Adrenozeptor-Polymorphismen mit postoperativem Vorhofflimmern bei Patienten nach aortokoronarer Bypass-Operation und/oder Herzklappenersatz. Medizinische Fakultät der Eberhard Karls Universität zu Tübingen 2005
  • Möhring, Alexandra
    Einfluss des Tyrosinkinaseinhibitors Imatinib auf das Enzym Poly(ADP-Ribose)Polymerase in Bcr-Abl-positiven hämatopoetischen Zellen. Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz Arndt Universität Greifswald 2005
  • Richter, Tanja
    Untersuchungen zur inter- und intraindividuellen Variabilität der enzymatischen Funktion von Cytochrom P450 CYP2B6. Naturwissenschaftlich- Mathematische Gesamtfakultät der Ruprecht-Karls-Universität Heidelberg 2005
  • Zukunft, Jörg
    Funktionelle Charakterisierung von Promotorpolymorphismen im humanen Cytochrom P450 2B6-Gen (CYP2B6). Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen 2005

Diploma Theses
  • Fiesel, Fabienne
    Einfluss von Bcr-Abl auf die p53-vermittelte Antwort nach genotoxischem Stress. Institut für Zellbiologie und Immunologie, Universität Stuttgart 2005
  • Sonnenberg, Maike
    Etablierung eines Zellmodells zur Untersuchung von Resistenzmechanismen gegenüber Iressa (Gefitinib). Universität Hohenheim, Stuttgart 2005