Anti-hormone Drug Metabolism and Pharmacodynamics

Dr. Thomas Mürdter

phone: ++49-711-8101 5974

Thomas Mürdter

Major Projects

Influence of pharmacogenetics on the metabolism of Selective Estrogen Receptor Modulators
Synthesis and analysis of phase I and II metabolites
Ex vivo models of human tumors

Selected References

PubMed Thomas E. Mürdter

Möller Y, Morkel M, Schmid J, Beyes S, Hendrick J, Strotbek M, Riemer P, Schmid S, Schmitt LC, Kontermann R, Mürdter T, Schwab M, Sers C, Olayioye MA. Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling. Oncotarget. 2016 Aug 16;7(33):53526-53539. FREE ARTICLE

Schaaf L, Schwab M, Ulmer C, Heine S, Mürdter TE, Schmid JO, Sauer G, Aulitzky WE, van der Kuip H. Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. Cancer Res. 2016 May 15;76(10):2868-75.

Johänning J, Heinkele G, Precht JC, Brauch H, Eichelbaum M, Schwab M, Schroth W, Mürdter TE. Highly sensitive simultaneous quantification of estrogenic tamoxifen metabolites and steroid hormones by LC-MS/MS. Anal Bioanal Chem. 2015 Sep;407(24):7497-502. FREE ARTICLE

Saladores P, Mürdter T, Eccles D, Chowbay B, Zgheib NK, Winter S, Ganchev B, Eccles B, Gerty S, Tfayli A, Lim JS, Yap YS, Ng RC, Wong NS, Dent R, Habbal MZ, Schaeffeler E, Eichelbaum M, Schroth W, Schwab M, Brauch H. Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer. Pharmacogenomics J. 2015 Feb;15(1):84-94. FREE ARTICLE

Heinkele G, Geditz MC, Ganchev B, Kerb R, Hofmann U, Mürdter TE. A new [2H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates. J Labelled Comp Radiopharm. 2014 Oct;57(12):699-703. FREE ARTICLE

Dickschen K, Eissing T, Mürdter T, Schwab M, Willmann S, Hempel G. Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling. Springerplus. 2014 Jun 5;3:285. FREE ARTICLE

Precht JC, Schroth W, Klein K, Brauch H, Krynetskiy E, Schwab M, Mürdter TE. The letrozole phase 1 metabolite carbinol as a novel probe drug for UGT2B7. Drug Metab Dispos. 2013 Nov;41(11):1906-13. FREE ARTICLE

Mürdter TE, Kerb R, Turpeinen M, Schroth W, Ganchev B, Böhmer GM, Igel S, Schaeffeler E, Zanger U, Brauch H, Schwab M. Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites. Hum Mol Genet. 2012 Mar 1;21(5):1145-54. FREE ARTICLE

Major Networks and Collaborations

TAMENDOX: Genotype and phenotype guided supplementation of TAMoxifen standard therapy with ENDOXifen in breast cancer patients

Extramural Funding

BMBF (Federal Ministry of Education and Research): Initiative Individualized Medicine: TAMENDOX
DFG (German Research Foundation): The role of agonistic metabolites in Tamoxifen resistance

Curriculum Vitae Thomas Mürdter, PhD

Affiliation

Deputy Head at the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP), Stuttgart, Germany
Research Group Leader Drug Sensitivity and Disease / Tumor Models

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart Germany
phone: ++49-711-8101 5974
fax: ++49-711-859295
email: thomas.muerdter@ikp-stuttgart.de

Education and Professional Career

Since 1997	Scientist at Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
1997	PhD in Chemistry. Thesis: Distribution, tumour selectivity, and bio-activation of doxorubicin in the isolated perfused human lung model.
1994-1997	PhD studies at Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
1992-1994	Deputy head of the Department of Polymer and Environmental Analysis at the Institute of Polymeric Sciences, Stuttgart, Germany
1991-1992	Research fellow at the Fraunhofer Institute for Interfacial Engineering and Biotechnology
1991	Diploma Thesis at the Department of Chemical Microbiology at the Fraunhofer Institute for Interfacial Engineering and Biotechnology: Degradation of trichloroethylene by the alcaligenes denitrificans ssp xylosoxidans strain JE95
1988-1991	Graduate studies in Chemistry with elective subject Biochemistry at University of Stuttgart
1988	Industrial traineeship at PLIVA Ltd. Zagreb, Yugoslavia
1984-1987	Undergraduate studies in Chemistry at University of Stuttgart

Professional Memberships

Since 1998: Member of the DGTP (German Society of Toxicology and Pharmacology)