Anti-hormone Drug Metabolism and Pharmacodynamics
Major Projects
- Influence of pharmacogenetics on the metabolism of Selective Estrogen Receptor Modulators
- Synthesis and analysis of phase I and II metabolites
- Ex vivo models of human tumors
Selected References
- Schaaf L, Schwab M, Ulmer C, Heine S, Mürdter TE, Schmid JO, Sauer G, Aulitzky WE, van der Kuip H. Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. Cancer Res. 2016 May 15;76(10):2868-75.
Major Networks and Collaborations
- TAMENDOX: Genotype and phenotype guided supplementation of TAMoxifen standard therapy with ENDOXifen in breast cancer patients
Extramural Funding
- BMBF (Federal Ministry of Education and Research): Initiative Individualized Medicine: TAMENDOX
- DFG (German Research Foundation): The role of agonistic metabolites in Tamoxifen resistance
Curriculum Vitae Thomas Mürdter, PhD
Affiliation
Deputy Head at the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP), Stuttgart, Germany
Research Group Leader Drug Sensitivity and Disease / Tumor Models
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart Germany
phone: ++49-711-8101 5974
fax: ++49-711-859295
email: thomas.muerdter@ikp-stuttgart.de
Research Group Leader Drug Sensitivity and Disease / Tumor Models
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart Germany
phone: ++49-711-8101 5974
fax: ++49-711-859295
email: thomas.muerdter@ikp-stuttgart.de
Education and Professional Career
Since 1997 | Scientist at Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology |
1997 | PhD in Chemistry. Thesis: Distribution, tumour selectivity, and bio-activation of doxorubicin in the isolated perfused human lung model. |
1994-1997 | PhD studies at Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology |
1992-1994 | Deputy head of the Department of Polymer and Environmental Analysis at the Institute of Polymeric Sciences, Stuttgart, Germany |
1991-1992 | Research fellow at the Fraunhofer Institute for Interfacial Engineering and Biotechnology |
1991 | Diploma Thesis at the Department of Chemical Microbiology at the Fraunhofer Institute for Interfacial Engineering and Biotechnology: Degradation of trichloroethylene by the alcaligenes denitrificans ssp xylosoxidans strain JE95 |
1988-1991 | Graduate studies in Chemistry with elective subject Biochemistry at University of Stuttgart |
1988 | Industrial traineeship at PLIVA Ltd. Zagreb, Yugoslavia |
1984-1987 | Undergraduate studies in Chemistry at University of Stuttgart |
Professional Memberships
Since 1998: Member of the DGTP (German Society of Toxicology and Pharmacology)