The lung as a drug target in pharmacology
There is increasing evidence that the lung is an important drug target for the treatment of different diseases such as asthma, COPD or lung cancer. In this context, we have recently established the animal model of the isolated perfused lung to investigate pharmacokinetics, such as adsorption and metabolite formation of drugs of interest following intravasal oder inhalative application and to study pharmacodynamics, e.g. respiratory parameters in response to drugs. In addition, the model of isolated lung perfusion in transgenic mice may contribute to the understanding of pathophysiology of lung diseases.
Major Projects
- Pulmonary pharmacokinetics and pharmacodynamics using the model of the isolated perfused lung.
PD Dr. med. Susanne Ammon-Treiber
phone: ++49-7071-29 72263
Selected References
- Ammon-Treiber S, Grecksch G, Angelidis C, Vezyraki P, Höllt V, Becker A. (2008) Emotional and learning behaviour in mice overexpressing heat shock protein 70. Neurobiol Learn Mem. 90(2):358-364.
- Ammon-Treiber S, Stolze D, Höllt V (2007) Differential effects of mu-opioid receptor agonists in a hippocampal hypoxia/hypoglycemia model. Brain Res. 1183:60-65.
- Ammon-Treiber S, Grecksch G, Angelidis C, Vezyraki P, Höllt V, Becker A (2007) Pentylenetetrazol-kindling in mice overexpressing heat shock protein 70. Naunyn Schmiedebergs Arch Pharmacol 375(2):115-121
- Ammon-Treiber S, Stolze D, Schröder H, Loh H, Höllt V (2005) Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model. Neuropharmacology 49:1160-1169
- Ammon-Treiber S & Höllt V (2005) Morphine induced gene expression. Addict Biol 10 (1):81-89 (Review)
- Ammon-Treiber S, Grecksch G, Stumm R, Riechert U, Tischmeyer H, Reichenauer A, Höllt V (2004) Rapid, transient, and dose-dependent expression of Hsp70 messenger RNA in the rat brain after morphine treatment. Cell Stress Chaperones 9(2):182-197
- Ammon-Treiber S, Tischmeyer H, Riechert U, Höllt V (2004) Gene expression of transcription factors in the rat brain after morphine withdrawal. Neurochem Res 29(6):1267-1273
- Treiber G, Schwabe M, Ammon S, Walker S, Klotz U, Malfertheiner P (2004) Dyspeptic symptoms associated with Helicobacter pylori infection are influenced by strain and host specific factors. Aliment Pharmacol Ther 19 (2): 219-231
- Ammon S, Mayer P, Riechert U, Tischmeyer H, Höllt V (2003) Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal. Mol Brain Res 112:113–125
- Mayer P, Ammon S, Braun H, Tischmeyer H, Riechert U, Kahl E, Höllt V (2002) Gene expression profile after intense second messenger activation in cortical primary neurons. J Neurochem 82(5):1077–1086
Curriculum Vitae Susanne Ammon-Treiber, MD
Affiliation
Senior Scientist
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Auerbachstr. 112
D - 70376 Stuttgart Germany
phone: ++49-711-8101 3700
fax: ++49-711-859295
email: susanne.ammon-treiber@ikp-stuttgart.de
Laboratory address:
Department of Clinical Pharmacology,
Institute of Experimental and Clinical Pharmacology and Toxicology,
University Hospital Tübingen
Otfried-Müller Str. 45
72076 Tübingen, Germany
phone: ++49-7071-29–72263 or -72240
fax: ++49–7071-29-5035
email: susanne.ammon-treiber@med.uni-tuebingen.de
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Auerbachstr. 112
D - 70376 Stuttgart Germany
phone: ++49-711-8101 3700
fax: ++49-711-859295
email: susanne.ammon-treiber@ikp-stuttgart.de
Laboratory address:
Department of Clinical Pharmacology,
Institute of Experimental and Clinical Pharmacology and Toxicology,
University Hospital Tübingen
Otfried-Müller Str. 45
72076 Tübingen, Germany
phone: ++49-7071-29–72263 or -72240
fax: ++49–7071-29-5035
email: susanne.ammon-treiber@med.uni-tuebingen.de
Education and Professional Career
| 1983-1988 | Studies of pharmacy, University of Tübingen |
| 1988 | State licence as a pharmacist |
| 1989-1996 | Studies of medicine, University of Tübingen |
| 1992 | Experimental laboratory work at „Laboratoire National de Sante“, Luxembourg |
| 1996 | Graduation: M.D. (medical doctor) |
| 1996-1998 | First-year resident, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart |
| 1998 | State licence as a medical doctor |
| 1998-1999 | Postdoctoral research fellow, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart |
| 2000–2006 | Postdoctoral research fellow, Institute of Pharmacology and Toxicology, University of Magdeburg |
| 2001 | Board Certification as Clinical Pharmacologist |
| 2006 | Habilitation and venia legendi in Pharmacology (University of Magdeburg) |
| 2006–2008 | Employee, Homburg, Saarland University (Function as coordinator of medical teaching in internal medicine) |
| 2007 | Venia legendi in Experimental and Clinical Pharmacology (Saarland University, Homburg) |
| since 2008 | Senior Scientist, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; laboratory affiliation: Department of Clinical Pharmacology, University Hospital, University of Tübingen |
| 2010 | Venia legendi in Experimental and Clinical Pharmacology (University of Tübingen) |
Professional Memberships
German Society of Experimental and Clinical Pharmacology and Toxicology (DGPT)
German Society of Pharmaceutical Medicine (DGPharMed)
German Society of Pharmaceutical Medicine (DGPharMed)