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Pharmacogenetics/genomics of ADME Genes in Human Liver

ADME-genes are genes involved in the absorption, distribution, metabolism and/or excretion of foreign (xenobiotic) and endogenous substances, including most clinically and recreationally used drugs, plant toxins, environmental chemicals, as well as steroid hormones, bile acids, and many other endogenous metabolites and signaling molecules. ADME genes often are highly variably expressed (>100fold) interindividually which can lead to unpredictable drug response, toxicity or cancer. Factors that cause variability include sex, hormonal status, circadian rhythm, environmental exposure, genetic polymorphisms, disease states, or non-coding RNAs. Most of the important genes have been investigated for SNPs and their impact on expression or drug treatment outcome. Purpose of this project is to find new mechanisms, factors or candidates contributing to the variable expression of genes in the ADME group. 
Major Projects
  • Tissue “Biobank”:Liver
  • Inter- and intraindividual expression variability of ADME genes
  • Pharmacogenomics and Pharmacogenetics of Cytochrome P450s
  • Genomewide analysis of Polymorphisms and Gene Expression in Human Liver
  • Cell culture systems for hepatic pharmacogenetics research
Dr. Kathrin Klein

phone: ++49-711-8101 5648

Selected References

Curriculum Vitae Kathrin Klein, PhD

Acting Group Leader: PGx of drug metabolism enzymes (formerly UM Zanger)

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart Germany
phone: ++49-711-8101 5648
fax: ++49-711-859295
Education and Professional Career
1984-1988 Study of Biology at the University of Stuttgart
1989 Diploma Thesis (Institute of Biology, Biophysics department, University Stuttgart) “Zellzyklusanalysen an Monolayerkulturen und Multizellsphäroiden”
1990-1995 PhD (Institute of Industrial Genetics, University Suttgart) “Die Bedeutung von Saccharose-Stoffwechselgenen für die Bakterielle Isomaltulose-Herstellung”
1996-1998 Incentive Program of the Baden-Württemberg Ministry of Education and Science: Südzucker AG / Institute of Industrial Genetics: “Development of genetic methods to optimize the Palatinose yield using Saccharose-Mutase from P.rubrum”
1999 - present Postdoctoral fellow at Institute of Clinical Pharmacology in the Department of Pharmacogenetics
Professional Memberships
Since 2009: Member of International Society for the Study of Xenobiotics (ISSX)
Scientific Journal Editorial Board Memberships
Associate Editor of Frontiers in Pharmocogenetics