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Membrane Transport Proteins and Pharmacogenomics

Transporters play critical roles in the absorption, disposition, and elimination of numerous drugs that are in clinical use. Alterations in the expression and function of these transporters may significantly contribute to drug pharmacokinetics and the interindividual variability of drug response. Our research aims to unravel genetic and non-genetic factors that affect transporter expression and function. The long-term goal is to explore the impact of transporter Pharmacogenomics in disease cohorts already available at the Institute of Clinical Pharmacology.
 
 
 
 
 
 
 
 
 
Major Projects
  • Molecular cell biology of drug transporters
  • Functional characterization of drug transporters
  • Pharmacogenomics of drug transporters
Prof. Dr. Anne Nies

phone: ++49-711-8101 3729

Selected References
  • Drenberg C, Gibson AA, Pounds S, Shi L, Rhinehart D, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A. OCTN1 is a high-affinity carrier of nucleoside analogs. Cancer Res (2017) Apr 15;77:2102-2111.
  • Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT. Impact of membrane drug transporters to resistance of small molecule tyrosine kinase inhibitors. Trends Pharmacol Sci (2016);37:904-932
  • Nies AT, Damme K, Kruck S, Schaeffeler E, Schwab M. Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine. Arch Toxicol (2016);90:1555-1584
  • Emami Riedmaier A, Burk O, van Eijck BAC, Schaeffeler E, Müller S, Winter S, Zanger UM, Schwab M, Nies AT. Organic anion transporter 7: a novel pravastatin uptake transporter in human liver regulated by hepatocyte nuclear factor 4-alpha. Pharmacogenomics J (2016); 16:341-351.
  • Arlanov R, Lang T, Jedlitschky G, Schaeffeler E, Ishikawa T, Schwab M, Nies AT. Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally-damaging variant. Pharmacogenomics J (2016); 16(2):193-201.
  • Nies AT, Magdy T, Schwab M, Zanger UM. Role of ABC transporters in fluoropyrimidine-based chemotherapy response. Adv Cancer Res (2015);125:217-243
  • Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT. Impact of genetic polymorphisms of ABCB1 (MDR1, P-glycoprotein) on drug disposition and potential clinical implications: update of the literature. Clin Pharmacokinet (2015);54:709-735
  • Emami Riedmaier A, Fisel P, Nies AT, Schaeffeler E, Schwab M. Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. Trends Pharmacol Sci (2013);34:126-135
  • Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E (2009) Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SCL22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50, 1227-1240.

Curriculum Vitae Anne Nies, PhD

Affiliation
Head Membrane Transport Proteins

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Auerbachstrasse 112
70376 Stuttgart Germany
phone: ++49-711-8101 3729
fax: ++49-711-859295
email: anne.nies@ikp-stuttgart.de
Education and Professional Career
1984-1990 Studies of Biology, University of Düsseldorf, Germany
1990 Diploma in Biology, University of Düsseldorf
1990-1993 PhD thesis in Biology, University of Düsseldorf
1993 Dr. rer. nat. (Ph.D.) in Biology, University of Düsseldorf, on transport and metabolism of urate in the hepatopancreas of the lobster
1994-1996 Postdoctoral Research Fellow of the Deutsche Forschungsgemeinschaft at Tufts University, Department of Physiology (Boston, MA, USA), on the biochemistry und molecular biology of P-glycoprotein and other hepatic transport systems
1996-2007 Senior Research Scientist at the German Cancer Research Center, Division of Tumor Biochemistry, Heidelberg, Germany.
Research area: Molecular cell biology of ATP-dependent efflux pumps and uptake transporters in the plasma membrane
2004 Habilitation and venia legendi in Biochemistry, University of Heidelberg Medical School
Since 2007 Senior Group Leader and Head of Membrane Transport Proteins, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
Since 2008 Venia legendi in Biochemical Pharmacology, University of Tübingen Medical School, Germany
2014 Extraordinary professorship at the University of Tübingen Medical School